Call : 716-878-7793 for appointments or information


Call : 716-878-7793for appointments or information

*Correspondence author. ¶ Fellows and trainees.

  1. Jianye Yuan¶, Wensheng Liu, Serhan Karvar, Susan S. Baker, Wenjun He, Robert D. Baker, Guang Ji, Jianqun Xie, Lixin Zhu*, 2015, Potassium channel KCNJ15 is required for histamine stimulated gastric acid secretion, Am J Physiol Cell Physiol. Accepted.
  2. Peijian He, Luqing Zhao, Lixin Zhu, Edward Weinman, Roberto De Giorgio, Michael Koval, Shanthi Srinivasan,  Chris Yun, 2015, Coordinated assembly of NHE3, IRBIT, NHERF1, and ezrin ameliorates fluid malabsorption in diabetes, Journal of Clinical Investigation, Accepted.
  3. Cheng-yuan Lin, Man Zhang, Tao Huang, Li-ling Yang, Hai-bo Fu, Ling Zhao, Li-dan Zhong, Huai-xue Mu, Xiao-Ke Shi, Christina Fung-ping Leung, Bao-min Fan, Miao Jiang, Aiping Lu, Lixin Zhu, and Zhao-xiang Bian, 2015, Spexin Enhances Bowel Movement through Activating L-type Voltage-dependent Calcium Channel via galanin receptor 2 in mice, Scientific Reports, Accepted.
  4. Qin Feng¶, Susan S. Baker, Wensheng Liu, Ricardo A. Arbizu¶, Ghanim Aljomah¶, Maan Khatib¶, Colleen A. Nugent¶, Robert D. Baker, Trudy M. Forte, Yiyang Hu*, Lixin Zhu*, 2015, Increased apolipoprotein A5 expression in human and rat non-alcoholic fatty livers, Pathology, 47(4):341-348.
  5. Diana Moya¶, Susan S. Baker*, Wensheng Liu, Michael Garrick, Rafal Kozielski, Robert D. Baker, and Lixin Zhu*, 2015, Novel pathway for iron deficiency in pediatric non-alcoholic steatohepatitis, Clinical Nutrition, 34(3):549-56.
  6. Dingfeng Wu, Tianyi Qiu, Qingchen Zhang, Hong Kang, Shaohua Yuan, Lixin Zhu*, and Ruixin Zhu*, 2015, Systematic Toxicity Mechanism Analysis of Proton Pump Inhibitors: An In Silico Study, Chem. Res. Toxicol., 28 (3):419–430.
  7. Lixin Zhu*, Wensheng Liu, Razan Alkhouri¶, Robert D. Baker, Jonathan E. Bard, Eamonn M. Quigley, and Susan S. Baker, 2014, Structural changes in the gut microbiome of constipated patients, Physiological Genomics, 46(18):679-86.
  8. Razan H. Alkhouri¶, Susan S. Baker, Humaira Hashmi, Wensheng Liu, Robert D. Baker, Lixin Zhu, 2014, Paraoxonase Gene Expression in Pediatric Inflammatory Bowel Disease, J Clin Cell Immunol., 5:224.
  9. Serhan Karvar, Jo Suda, Lixin Zhu, Don C. Rocky, 2014, Distribution dynamics and functional importance of NHERF-1 on regulation of Mrp-2 trafficking in hepatocytes, Am J Physiol Gastrointest Liver Physiol., 307(8):C727-37.
  10. Jianye Yuan¶, Susan S. Baker*, Wensheng Liu, Razan Alkhouri¶, Robert D. Baker, Jianqun Xie, Guang Ji, and Lixin Zhu*, 2014, Endotoxemia unrequired in the pathogenesis of non-alcoholic steatohepatitis, Journal of Gastroenterology and Hepatology, 29(6):1292-8.
  11. Chuan Tian, Lixin Zhu, Dan Yu, Zhiwei Cao, Tingguo Kang, Ruixin Zhu, 2014, The Stereoselectivity of CYP2C19 on R- and S-isomer of Proton Pump Inhibitors, Chemical Biology & Drug Design, 83(5):610-621.
  12. Sonal Desai¶, Susan S. Baker, Wensheng Liu, Diana A. Moya, Richard W. Browne, Lucy Mastrandrea, Robert D. Baker, and Lixin Zhu*, 2014, Paraoxonase 1 and oxidative stress in pediatric non-alcoholic steatohepatitis, Liver International, 34(1): 110-117.
  13. Charles Watson, Lixin Zhu*, Shenheng Guan, Terry E. Machen, and John G. Forte, 2013, Reaction of proton pump inhibitors with model peptides results in novel products, Journal of Pharmacological Sciences, 122(3): 213-222.
  14. Lixin Zhu*, Susan S. Baker*, Chelsea Gill, Wensheng Liu, Razan Alkhouri¶, Robert D. Baker, Steven R. Gill, 2013, Characterization of the gut microbiome in non-alcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH, Hepatology, 57(2): 601-609.The second most highly cited article in Hepatology in 2013, cited 62 times as of August, 2014.

Highlighted by Nature Reviews (

  1. Wensheng Liu, Susan S. Baker, Jonathan Trinidad, Alma L. Burlingame, Robert D. Baker, John G. Forte, Lauren P. Virtuoso, Nejat K. Egilmez and Lixin Zhu*, 2013, Inhibition of lysosomal enzyme activities by proton pump inhibitors, Journal of Gastroenterology, 48(12):1343-52.
  2. Yida Zhang¶, Susan S. Baker, Robert D. Baker, Ruixin Zhu*, Lixin Zhu*, 2012, Systematic analysis of the gene expression in the livers of nonalcoholic steatohepatitis: Implications on potential biomarkers and molecular pathological mechanism, PLoS ONE. 7(12): e51131.
  3. Raza Patel¶, Susan S. Baker*, Wensheng Liu, Sonal Desai¶, Razan Alkhouri¶, Rafal Kozielski, Lucy Mastrandrea, Adil Sarfraz¶, Weijing Cai, Helen Vlassara, Mulchand S. Patel, Robert D. Baker, and Lixin Zhu*, 2012, Effect of dietary advanced glycation end products on mouse liver. PLoS ONE. 7(4): e35143.
  4. Lixin Zhu, 2011, Teaching the fundamentals of biological research with primary literature: learning from the discovery of the gastric proton pump. Bioscene: Journal of College Biology Teaching. 37(2):3-8.
  5. Shi Xu, Maria Edman, Mubashera S. Kothawala, Guoyong Sun, Lilian Chiang, Austin Mircheff, Lixin Zhu, Curtis Okamoto and Sarah Hamm-Alvarez, 2011, A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. Journal of Cell Science. 124:3503-3514.
  6. Wensheng Liu, Susan S. Baker, Robert D. Baker, Norma J. Nowak and Lixin Zhu*, 2011, Upregulation of hemoglobin expression by oxidative stress in hepatocytes and its implication in nonalcoholic steatohepatitis. PLoS ONE. 6(9): e24363.
  7. Wenjun He, Wensheng Liu, Catherine S. Chew, Susan S. Baker, Robert D. Baker, John G. Forte, and Lixin Zhu*, 2011, Acid secretion associated translocation of KCNJ15 in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol. 301:G591-G600.
  8. Jo Suda, Lixin Zhu, Serhan Karvar, 2011, Phosphorylation of radixin regulates cell polarity and mrp-2 distribution in hepatocytes. Am J Physiol Cell Physiol. 300(3):C416-C424.
  9. Lixin Zhu*, Susan S. Baker, Wensheng Liu, Meng-Hua Tao, Raza Patel¶, Norma J. Nowak and Robert D. Baker*, 2011, Lipid in the livers of adolescents with non-alcoholic steatohepatitis: combined effects of pathways on steatosis. Metabolism. 60(7):1001-1011.
  10. Jo Suda, Lixin Zhu, Curtis T. Okamoto, Serhan Karvar, 2011, Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion. Gastroenterology. 140(3): 868-878.
  11. Lixin Zhu, James Crothers, Jr., Rihong Zhou and John G. Forte, 2010, A possible mechanism for ezrin to establish epithelial cell polarity. Am J Physiol Cell Physiol. 299:C431-43.
  12. Susan S. Baker, Robert D. Baker, Wensheng Liu, Norma J. Nowak, and Lixin Zhu*, 2010, Role of alcohol metabolism in non-alcoholic steatohepatitis. PLoS ONE, 5(3): e9570.  

Selected Publications